1h-indazoles, benzothiazoles, 1,2-benzoisoxazoles,...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/08 (2006.01) A61K 31/4985 (2006.01) A61K 31/551 (2006.01) A61P 25/28 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2565984

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the .alpha.7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

L'invention concerne des ligands pour des récepteurs d'acétylcholine nicotinique (nAChR), l'activation de ces derniers, et le traitement des états pathologiques associés à des récepteurs d'acétylcholine nicotinique défectueux ou fonctionnant anormalement, en particulier pour le cerveau. De plus, l'invention concerne des nouveaux composés (indazoles et benzothiazoles), qui agissent comme des ligands pour un sous-type de nAChR .alpha.7, des procédés de préparation desdits composés, des compositions contenant lesdits composés et des procédés d'utilisation associés.

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