1h-indole-1-functional spla2 inhibitors

Details 1h-indole-1-functional spla2 inhibitors 1h-indole-1-functional spla2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2195569

A class of novel 1H-indole-1-functional compounds is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are 1H-indole-1-acetamides, 1H-indole-1- acetic acid hydrazides, and 1H-indole-1-glyoxylamides.

Classe de nouveaux composés à fonctionnalité 1H-indole en position 1, ainsi que l'utilisation desdits composés indole pour inhiber la libération d'acides gras induite par PLAs2 dans le traitement de troubles pathologiques tels que le choc septique. Lesdits composés sont des 1H-indole-1-acétamides, des hydrazides d'acide 1H-indole-1-acétique et des 1H-indole-1-glyoxylamides.

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