1h-indole-3-acetic acid hydrazide spla2 inhibitors

Details 1h-indole-3-acetic acid hydrazide spla2 inhibitors 1h-indole-3-acetic acid hydrazide spla2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/04 (2006.01) A61K 31/405 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 209/22 (2006.01) C07D 209/24 (2006.01) C07D 209/30 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2121321

ABSTRACT A class of novel 1H-indole-3-acetic acid hydrazides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock.

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