[1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or...

Details [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or... [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2704266

The present invention relates to compounds of formula (I) and (IA) useful as inhibitors of protein kinase (la). The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. (a) : in particular protein kinase C theta, wherein A and A' are independently -N- or -C(R+) -. Ring B is five- or six-membered saturated carbocyclic or heterocyclic R1, R2, R3, R4, R5, R6, R7, x and y are as described herein.

La présente invention concerne des composés de formule (I) et (IA) utiles en tant qu'inhibiteurs de protéine kinase (1a). L'invention concerne également des compositions acceptables sur le plan pharmaceutique renfermant lesdits composés et des procédés d'utilisation des compositions dans le traitement de diverses maladies, diverses affections ou divers troubles. L'invention a également pour objet des procédés de préparation des composés de l'invention. (a) : en particulier la protéine kinase C thêta. Formule (I) ou (IA), dans laquelle A et A' représentent indépendamment -N- ou -C(R+) -. Le cycle B représente un cycle carbocyclique ou hétérocyclique saturé à cinq ou six chaînons. R1, R2, R3, R4, R5, R6, R7, x et y sont tels que décrits dans ce document.

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