1h-pyrrolo[3,2-b]pyridine-3-carboxylic acid amides

Details 1h-pyrrolo[3,2-b]pyridine-3-carboxylic acid amides 1h-pyrrolo[3,2-b]pyridine-3-carboxylic acid amides

C - Chemistry, Metallurgy

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01) C07D 519/00 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2467542

Disclosed are 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid amides that bind to the benzodiazepine site of GABAA receptors. Such compounds can be used to modulate ligand binding to GABAA receptors in vivo and in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals.

L'invention concerne des amides d'acide 1H-pyrrolo[3,2-b]pyridine-3-carboxylique qui se lient au site benzodiazépine de récepteurs GABA¿A?. De tels composés peuvent être utilisés pour moduler la liaison de ligands à des récepteurs GABA¿A? in vivo et in vitro et sont particulièrement utiles dans le traitement de divers troubles du système nerveux central chez l'homme, les animaux de compagnie domestiqués et le bétail.

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