C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/96 (2006.01) A61K 31/517 (2006.01) A61P 25/08 (2006.01) A61P 25/18 (2006.01) C07D 207/32 (2006.01) C07D 231/12 (2006.01) C07D 237/08 (2006.01) C07D 249/06 (2006.01) C07D 307/16 (2006.01) C07D 307/54 (2006.01) C07D 309/12 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2601986
The present invention relates to l H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as AMPA-receptor ligands, in particular for the treatment of epilepsy or schizophrenia, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) and combinations comprising compounds of formula (I) are disclosed.
L'invention se rapporte à l H-Quinazoline-2, 4-diones de formule (I), dans laquelle R1 et R2 sont tels que définis dans la description, à leur préparation, à leur utilisation en tant que ligands du récepteur AMPA, en particulier dans le traitement de l'épilepsie ou de la schizophrénie, ainsi qu'à des compositions pharmaceutiques les renfermant. L'invention concerne également des produits intermédiaires destinés à la fabrication de composés de formule (I) et à des combinaisons contenant les composés de formule (I).
Allgeier Hans
Auberson Yves
Carcache David
Floersheim Philipp
Froestl Wolfgang
Fetherstonhaugh & Co.
Novartis Ag
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