1h-quinolin-4-one compounds, with affinity for the gaba...

Details 1h-quinolin-4-one compounds, with affinity for the gaba... 1h-quinolin-4-one compounds, with affinity for the gaba...

C - Chemistry, Metallurgy

07

D

C07D 215/06 (2006.01) A61K 31/47 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) C07D 215/18 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2660421

The invention provides new 1H-quinolin-4-one compounds of formula (I), wherein R1, R2, R3, R4 and R 5 have different meanings, and pharmaceutically acceptable salts and hydrates thereof. Compounds of formula (I) are useful for treating or preventing diseases associated with GABAA receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic procedures for preparing said compounds.

La présente invention concerne de nouveaux composés de 1H-quinolin-4-one répondant à la formule (I), R1, R2, R3, R4 et R5 ayant différentes significations, et leurs sels et hydrates pharmaceutiquement acceptables. Les composés répondant à la formule (I) se révèlent utiles pour traiter ou prévenir des maladies associées à la modulation des récepteurs GABAA, l'anxiété, l'épilepsie, les troubles du sommeil, notamment l'insomnie, et pour induire une hypnose associée à une sédation, une anesthésie, le sommeil et une relaxation musculaire. L'invention concerne également des procédés de synthèse servant à préparer lesdits composés.

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