1n-alkyl-n-arylpyrimidinamines and derivatives thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/28 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 213/74 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 251/12 (2006.01) C07D 251/18 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/02 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 413

Patent

CA 2174080

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula (I), wherein R1, R3, R4, R5, Z, Y, V, X, X', J, K, L, and M are as defined herein.

La présente invention se rapporte à des composés nouveaux, à leurs compositions pharmaceutiques ainsi qu'à leurs procédés d'utilisation dans le traitement des troubles affectifs et de l'appétit, de l'anxiété, de la dépression, du stress post-traumatique, de la paralysie supranucléaire, du syndrome de l'hyperexcitabilité de l'intestin, de l'immunosuppression, de la maladie d'Alzheimer, des maladies gastro-intestinales, de l'anorexie nerveuse, de l'état de privation de drogue ou d'alcool, de la toxicomanie, des états inflammatoires, ou des problèmes de fécondité. Ces nouveaux composés répondent à la formule (I) dans laquelle R?1¿, R?3¿, R?4¿, R?5¿, Z, Y, V, X, X', J, K, L et M sont tels que définis dans l'invention.

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