1n-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-6'n-methyl-3',4'-...

Details 1n-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-6'n-methyl-3',4'-... 1n-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-6'n-methyl-3',4'-...

C - Chemistry, Metallurgy

07

H

260/230.5

C07H 15/22 (2006.01) C07H 15/236 (2006.01)

Patent

CA 1050537

1N-(.alpha.-Hydroxy-.omega.-aminoalkanoyl)-6'N-methyl-3',4'- dideoxykanamycin B and the production thereof Abstract of the Disclosure A number of 1N-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-6'N- methyl-3',4'-dideoxykanamycin B derivatives have been found to possess excellent antibacterial activity against most kanamycin susceptible and resistant organisms. In particular, 1N-(DL-isoseryl)-6'N- methyl-3',4'-dideoxykanamycin B, 1N-(L-isoseryl)- 6'N-methyl-3',4'-dideoxykanamycin B, 1N-(L-4-amino-2- hydroxybutyryl)-6'N-methyl-3',4'-dideoxykanamycin B and 1N-(L-5-amino-2-hydroxyvaleryl)-6'N-methyl-3'-4'- dideoxykanamycin B, or an acid addition salt thereof possess these highly desirable attributes. -1-

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