(1r,1'r)-atracurium salts separation process

Details (1r,1'r)-atracurium salts separation process (1r,1'r)-atracurium salts separation process

C - Chemistry, Metallurgy

07

D

C07D 217/20 (2006.01) C07B 57/00 (2006.01)

Patent

CA 2681060

Provided is a method for separating cisatracurium from a mixture of atracurium isomers, which method includes eluting from a Reverse Phase (RP) stationary phase with a mobile phase in which the isomers are stable. The method of the present invention can be conveniently and inexpensively scaled up.

L'invention porte sur un procédé de séparation de cisatracurium dans un mélange d'isomères d'atracurium. Ce procédé comprend l'élution d'une phase stationnaire (phase inverse (RP)) par une phase mobile dans laquelle les isomères sont stables. Le procédé de la présente invention peut être appliqué à plus grande échelle de façon commode et abordable.

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