(1r,6s)-2-azabicyclo[4.3.0] nonane-8,8-diphosphonic acid and...

Details (1r,6s)-2-azabicyclo[4.3.0] nonane-8,8-diphosphonic acid and... (1r,6s)-2-azabicyclo[4.3.0] nonane-8,8-diphosphonic acid and...

C - Chemistry, Metallurgy

07

F

C07F 9/576 (2006.01) A61K 31/663 (2006.01) A61K 31/675 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2672191

Disclosed is a new composition of matter, substantially enantiomerically pure (1R,6S)-2-Azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, methods of preparing this new composition of matter, a pharmaceutical composition comprising the new composition, and administration of the composition in methods of treating bone disorders such as osteoporosis, osteolytic bone metastasis, rheumatoid arthritis and osteoarthritis.

L'invention concerne une nouvelle composition d'acide (1R,6S)-2-azabicyclo-[4.3.0]nonane-8,8-diphosphonique, sensiblement énantiométiquement pure, des procédés de préparation de cette nouvelle composition, une composition pharmaceutique comportant la nouvelle composition, et l'administration de la composition dans des procédés de traitement de troubles osseux tels que l'ostéoporose, la métastase osseuse ostéolytique, la polyarthrite rhumatoïde et l'arthrose.

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