(1s) -hydroxyalkyl-oxapenem-3-carboxylic acids and their use...

Details (1s) -hydroxyalkyl-oxapenem-3-carboxylic acids and their use... (1s) -hydroxyalkyl-oxapenem-3-carboxylic acids and their use...

C - Chemistry, Metallurgy

07

F

C07F 9/547 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/53 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 503/00 (2006.01) C07F 7/10 (2006.01) C07D 498/047 (1990.01)

Patent

CA 2085834

ABSTRACT The invention relates to 1-oxapenem-3-carboxylic acids of the following structure: Image in which R1, R3, R4 and R5 independently of one another denote pharmaceutically acceptable groups which are connected to the other part of the molecule via carbon- carbon single bonds and which contain 1 to 10 carbon atoms, and in which R2 is hydrogen, alkyl or acyl having up to 10 carbon atoms or an inorganic acid residue. These compounds, as well as their pharmaceutically acceptable salts, esters and amide derivatives are especially useful betalactamase inhibitors. Subject of the invention are also pharmaceutical preparations containing these compounds and procedures for medication, as well as procedures for the preparation of such compounds.

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