2-0- and 5-0-substituted 1.4;3.6-dianhydrohexitol...

Details 2-0- and 5-0-substituted 1.4;3.6-dianhydrohexitol... 2-0- and 5-0-substituted 1.4;3.6-dianhydrohexitol...

C - Chemistry, Metallurgy

07

D

260/361.2, 260/2

C07D 493/04 (2006.01)

Patent

CA 1184916

Abstract 2?O- and 5-O-substituted 1.4;3.6-dianhydrohexitol mononitrates of general formula I, Image (I) wherein R is a halogen-substituted phenyl group, a methanesul- phonyl or nicotinoyl group, as well as their physiologically acceptable acid-addition salts, insofar as R signifies the nicotinoyl group. Processes for the preparation of said compounds and pharma- ceutical compositions containing said compounds. The compounds according to the invention possess coronary flowthrough-increasing, spasmolytic, blood pressure-lowering, negatively inotropic and heart frequency-lowering effectiveness.

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