(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4...

Details (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4... (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4...

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/4035 (2006.01) A61P 35/00 (2006.01) C07C 317/28 (2006.01)

Patent

CA 2479666

Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2- methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discused. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3- Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3- dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4.

L'invention concerne (+)-2-[1-(3-Ethoxy-4-méthoxyphényl)-2-méthylsulfonyléthyl]-4-acétylaminoisoindoline-1,3-dione stéréomériquement pure, sensiblement dépourvu de ses isomères (-), et promédicaments, métabolites, polymorphes, sels, solvates, hydrates, et ses clathrates. L'invention concerne également des procédés d'utilisation et des compositions pharmaceutiques comprenant l'isomère optique (+) de 2-[1-(3-Ethoxy-4-méthoxyphényle)-2-méthylsulfonyléthyle]-4-acétylaminoisoindoline-1,3-dione. Les procédés décrits comportent des procédés de traitement et/ou de prévention de troubles améliorés par réduction des niveaux de TNF-.alpha. ou l'inhibition de PDE4.

Affiliated with

Also associated with

Rating

(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1486974