C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 5/44 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01)
Patent
CA 2667007
The present invention is directed to 2- [l-phenyl-5 -hydroxy or methoxy-4alpha- methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives of formula I (I) as glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.
L'invention concerne des derivés de 2- [l-phényl-5 -hydroxy ou méthoxy-4alpha- méthyl-hexahydrocyclopenta[f]indazol-5-yl]éthyle phényle correspondant à la formule (I) utilisés comme ligands de récepteur de glucocorticoïde utiles dans le traitement de diverses maladies ou états auto-immunes ou inflammatoires. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation.
Bungard Christopher J.
Manikowski Jesse J.
Meissner Robert
Perkins James J.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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