C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/263
C07D 401/04 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 215/38 (2006.01) C07D 221/04 (2006.01) C07D 221/22 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2011346
The present invention is directed to 2-(1-piperazinyl)-4-phenyl-cycloalkano-pyridine derivatives of the formula (I): (see fig. I) wherein n is 3, 4, 5, 6 or 7; R1 is hydrogen atom, C1-C10 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C6 cycloalkyl-(C1-C4) alkyl, hydroxy-(C2-c6) alkyl, C1-C3 alkoxy-(C2-C6) alkyl, acyloxy (C2-C6) alkyl, unsubstituted or substituted aroyl-(C1-C6) alkyl, unsubstituted or substituted aryl, heteroaryl, or acyl; R2 and R3 are the same or different and each represent hydrogen atom, halogen atom, C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl, or hydroxy; R4, R5 and R6 are the same or different and each represent hydrogen atom, C1-C6 alkyl, or phenyl, or two of R4, R5 and R6 combine to form a single bond or C1-C3 alkylene; R7 and R8 are the same or different and each represent hydrogen atom or C1-C3 alkyl; m is 2 or 3, or an acid addition salt thereof. These derivatives are useful as psychotropic drugs. The invention is also directed to processes for the preparation of the derivatives.
Furukawa Kiyoshi
Hino Katsuhiko
Kai Naoki
Kon Tatsuya
Ochi Yoshiaki
Dainippon Sumitomo Pharma Co. Ltd.
Kirby Eades Gale Baker
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