C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/416 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C07D 231/56 (2006.01) C07D 401/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2510850
Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating ophthalmic diseases and cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma,rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés d'indazoles qui modulent et/ou inhibent les maladies ophtalmiques et l'activité de certaines protéines kinases. Lesdits composés et les compositions pharmaceutiques les contenant peuvent induire une transduction du signal des tyrosines kinases et moduler et/ou inhiber ainsi une prolifération cellulaire indésirable. L'invention concerne également l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes de traitement de maladies ophtalmiques ainsi que du cancer et d'autres affections associées à une angiogenèse et/ou à une prolifération cellulaire indésirables, telles que la rétinopathie diabétique, le glaucome néovasculaire, la polyarthrite rhumatoïde et le psoriasis, par administration de quantités efficaces desdits composés.
Borchardt Allen John
Kania Robert Steven
Palmer Cynthia Louise
Pfizer Inc.
Smart & Biggar
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