2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Details 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2395205

2-(1H-Indol-3-yl)-2-oxo-acetamides having antitumor activity, in particular against solid tumors, more precisely colon and lung tumors, of the following formula (I) wherein Y is an oxygen of sulfur atom and X, R1, R2, R3, R4 and R5 are as defined in claim 1.

La présente invention concerne des antitumoraux à base de 2-(1h-indol-3-yl)-2-oxo-acétamides, agissant particulièrement contre les tumeurs solides, et en particulier contre les tumeurs du colon et du poumon. Ces antitumoraux sont représentés par la formule générale (I) dans laquelle Y est un atome d'oxygène ou de soufre, X, R¿1?, R¿2?, R¿3?, R¿4? et R¿5? étant tels que définis par la revendication 1.

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