[2.2.2] bicyclic derivatives and methods of use

Details [2.2.2] bicyclic derivatives and methods of use [2.2.2] bicyclic derivatives and methods of use

A - Human Necessities

61

K

A61K 31/46 (2006.01) A61P 25/08 (2006.01)

Patent

CA 2747803

Administration of a salt of bi-cyclo [2.2.2] octane-2-carbonic acid reduces dysphoria in dysphoric subjects, ameliorates ethanol craving in alcoholics, reduces the erythrocyte sedimentation rate and the level of liver function markers (AST, ALT, and bilirubin) in human subjects, and reduces the number or strength of seizures in epileptics.

Selon l'invention, l'administration d'un sel d'acide bi-cyclo [2.2.2] octane-2-carbonique réduit la dysphorie chez les sujets dysphoriques, améliore l'état de manque en éthanol chez les alcooliques, réduit le taux de sédimentation des érythrocytes et le taux de marqueurs de la fonction hépatique (AST, ALT et bilirubine) chez les sujets humains, et réduit le nombre ou la violence des crises chez les épileptiques.

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