2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-di-...

Details 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-di-... 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-di-...

C - Chemistry, Metallurgy

07

D

260/294.2

C07D 211/90 (2006.01)

Patent

CA 1206967

Abstract of the Disclosure 2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4- dihydropyridine-4-carboxamide) glutaric acid of the formula: Image (I) and the pharmaceutically acceptable disodium salt thereof are prepared by reacting the pentafluorophenyl ester of 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid with glutamic acid in the presence of di-iso- propylethyl amine in an inert organic solvent; or by reacting 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydro- isonicotinic acid with glutamic acid and dicyclohexyl- carbodiimide in the presence of l-hydroxybenzotriazole in an inert organic solvent; or by reacting the bis- trimethylsilyl ester of glutamic acid with a mixed anhydride of 2,6-dimethyl-3,5-diethoxycarbonyl-1,4- dihydropyridine-4-carboxylic acid and isobutyl ester of carbonic acid at a temperature from 0 to -10°C in an inert organic solvent; and optionally converting the acid of formula (I) thus obtained into the pharmaceutically acceptable disodium salt thereof. The acid of the formula (I) and its disodium salt possess antiarrhythmic activity.

438515

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