2-(2-aminothiazol-4-yl)-n-(imidazolidin-2-on-1-yl)-2-...

Details 2-(2-aminothiazol-4-yl)-n-(imidazolidin-2-on-1-yl)-2-... 2-(2-aminothiazol-4-yl)-n-(imidazolidin-2-on-1-yl)-2-...

C - Chemistry, Metallurgy

07

D

260/104.1, 260/1

C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 417/12 (2006.01) C07D 501/02 (2006.01) C07D 501/22 (2006.01) C07D 501/24 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01) C07D 501/38 (2006.01) C07D 501/46 (2006.01) C07D 501/59 (2006.01)

Patent

CA 1161429

ABSTRACT OF THE DISCLOSURE A pure syn-form cephalosporin of the formula Image in which n is 2, 3 or 4, R1 represents a hydrogen atom, a pharmaceutically acceptable metal cation, an ammonium cation of a pharmaceutically acceptable nitrogen base, a radical of an ester of, if another part of the molecule contains a positive charge, a negative charge, T denotes -CH3, -CH2-O-CO-CH3, Image [in which Z denotes O or S), -O-CO-NH2, Image or Image and Y denotes -S- or -?-, is produced by reacting aminothiazolylglyoxylic acid of the formula ABSTRACT: Image with the hydrazine compound of the formula Image to give a syn-acid of the formula Image and reacting the syn-acid with a halogenating agent, and then in the absence of a base with a 7-aminocephalosporanic acid derivative of the formula Image The pure syn-form of the cephalosporin is considerably more active as an antibiotic than the antii-form.

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