C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277.9
C07D 401/12 (2006.01) C07D 213/02 (2006.01) C07D 235/28 (2006.01) C07D 417/12 (2006.01)
Patent
CA 1055033
Abstract of the Disclosure New compounds of the formula Image Het and their therapeutically acceptable salts, in which R and R3 are the same or different and are selected from the group consisting of hydrogen, alkyl, halogen, cyano, carboxy, carboxyalkyl, carboalkoxy, carboalkoxyalkyl, car- bamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl and acyl in any position, R4 is selected from the group consisting of hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alk- ylcarbonylmethyl, alkoxycarbonylmethyl, alkylsulfonyl, R6 is a straight or branched alkyl group having 1 to 4 carbon atoms, whereby at most one methy- lene group is present between S and Het and Het is selected from the group consisting of imidazolyl, imidazolinyl, benzimidazolyl, thiazolyl, thiazol- inyl, quinolyl, piperidyl and pyridyl, which may be further substituted pre- ferably in 3 to 5 position with lower alkyl groups such as methyl, ethyl or propyl or with halogen substituents such as chloro and bromo, are described as having the property of inhibiting the secretion of gastric acid. Several processes for the preparation of the new compounds are given.
239643
Berntsson Peder B.
Carlsson Stig A. I.
Garberg Lars E.
Junggren Ulf K.
Sjostrand Sven E.
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