2-¬2-heterocyclic-methylthio)-ethylamino|-3- nitropyrrole...

Details 2-¬2-heterocyclic-methylthio)-ethylamino|-3- nitropyrrole... 2-¬2-heterocyclic-methylthio)-ethylamino|-3- nitropyrrole...

C - Chemistry, Metallurgy

07

D

260/300, 260/280

C07D 403/00 (2006.01) C07D 207/42 (2006.01)

Patent

CA 1124719

ABSTRACT This invention relates to nitro compounds which show activity as histamine H2-receptor antagonists. The compounds of the invention are of Structure Image where Het is an optionally substituted 5- or 6- membered fully-unsaturated heterocycle containing at least one nitro- gen atom, or a furan or thiophene ring substituted by a substituted or unsubstituted aminoalkyl group; Z is sulfur, methylene or oxygen, m is 0, 1 or 2, n is 2 or 3 with m + n being 3 or 4; R3 is hydrogen or various substituents; and R4 is hydrogen or lower alkyl; and acid addition salts thereof. The compounds can be prepared by condensing appropriate moieties containing the Het and pyrrole portions of the desired product. The compositions of the invention contain at least one of the compounds of the invention. and a pharmaceutical carrier.

328542

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