2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4...

Details 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4... 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/437 (2006.01) A61P 33/00 (2006.01) C07D 209/04 (2006.01) C07D 209/30 (2006.01)

Patent

CA 2694380

Pyrrolo[3,2-c]pyridine-4-one-2-indolinone compounds, especially 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7- dihyd ro-1H-pyrrol[3,2-c]pyridine-4(5H)-one compounds. Their preparation and pharmaceutical composition, and pharmaceutical use as protein kinase inhibitors. (see formula I)

L'invention porte sur des composés de pyrrolo[3,2-c]pyridine-4-one-2-indolinone, notamment sur des composés de 2-(2-oxoindoline-3-ylidène)méthyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-c]pyridine-4(5H)-one. L'invention porte également sur leur préparation et sur une composition pharmaceutique les comprenant, et sur leur utilisation pharmaceutique en tant qu'inhibiteurs de protéine kinase.

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