2,3(1h,4h)-quinoxalinediones

Details 2,3(1h,4h)-quinoxalinediones 2,3(1h,4h)-quinoxalinediones

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/495 (2006.01) C07D 487/14 (2006.01)

Patent

CA 2097141

O.Z. 0050/43262 Abstract of the Disclosure: 2,3(1H,4H)-quinoxalinediones of the formula I Image I where R1 is hydrogen, an aliphatic radical which has up to 12 carbons and can be substituted by one of the following: phenyl, cyclopentyl, cyclohexyl or -CO-R3, -CO-O-R3 or -Co-NH-R3, where R3 is hydrogen, C1-C4-alkyl, phenyl, benzyl or 1-phenylethyl, a cycloaliphatic radical with up to 12 carbons or phenyl, where the cyclic groups in R1 can have up to three of the following substituents: C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, halogen, nitro, cyano, -CO-O-R3 and -CO-NH-R3; R2 is 1-pyrrolyl which can have up to two of the follow- ing substituents: C1-C4-alkyl, phenyl, phenylsulfonyl, nitro, cyano and -CO-O-R3, -CO-NH-R3, -CH2-O-R3, -O-R3 and -CH=NO-R3 R radicals are identical or different and are the follow- ing: C1-C4-alkyl, C1-C4-alkoxy, trifluoromethyl, trichloro- methyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and -Co-o-R3 and -CO-NH-R3 as well as a fused-on benzene ring; n is 0-3, and 2,3(1H,4H)-quinoxalinediones I' O.Z. 0050/43262 Image I' where R1 has the stated meanings, are suitable as drugs in human and veterinary medicine.

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