2-{3-[4-(2-t-butyl-6- trifluoromethylpyridin-4-yl)...

Details 2-{3-[4-(2-t-butyl-6- trifluoromethylpyridin-4-yl)... 2-{3-[4-(2-t-butyl-6- trifluoromethylpyridin-4-yl)...

C - Chemistry, Metallurgy

07

D

C07D 239/56 (2006.01) A61K 31/395 (2006.01) A61K 31/497 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 1/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/24 (2006.01) A61P 43/00 (2006.01) C07D 239/42 (2006.01) C07D 239/46 (2006.01) C07D 295/125 (2006.01) C07D 403/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2301297

The invention relates to the fumaric acid salt from 2-{3-[4-(2-T-butyl-6- trifluoromethylpyridin-4-yl) piperazin-1-yl] propylmercapto} pyrimidin-4-ol and to pharmaceutical agents containing said salt. The salt can be used for treating diseases which respond to dopamine-D3 ligands. It is very stable at a low pH and is therefore especially suitable for oral administration.

L'invention concerne un acide fumarique de 2-{3-(4-(2-t-Butyl-6- trifluorométhylpyrimidin-4-yl) pipérazin-1-yl] propylmercapto} pyrimidin-4-ol et des substances pharmaceutiques contenant ce sel. Ce sel peut être utilisé pour le traitement de maladies qui répondent aux ligands dopamine-D¿3?. Grâce à une stabilité améliorée pour un faible pH, ce sel convient particulièrement à une administration par voie orale.

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