2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a) quinoxalin-...

Details 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a) quinoxalin-... 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a) quinoxalin-...

C - Chemistry, Metallurgy

07

D

260/265.5

C07D 487/04 (2006.01)

Patent

CA 1093557

ABSTRACT OF THE DISCLOSURE The present invention provides a compound of the formula: Image or Image wherein R is hydrogen, (lower) alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R1 is hydrogen or (lower)alkyl; R2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9- position; R3 is hydrogen or (lower)alkyl; and R4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9- position; or the non-toxic acid addition salts thereof. The compounds exert a hypotensive effect in hypertensive warm- blooded animals, as evidenced by pharmacological evaluation in standard test procedures.

273768

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