2,3,4,5-tetrahydro-1h-¬1,4|benzodiazepine-3-hydroxamic acid...

Details 2,3,4,5-tetrahydro-1h-¬1,4|benzodiazepine-3-hydroxamic acid... 2,3,4,5-tetrahydro-1h-¬1,4|benzodiazepine-3-hydroxamic acid...

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/5513 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2356267

Compounds having formula (1) are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.

L'invention concerne des composés, représentés par la formule (1) ci-après, qui sont utiles dans le cadre du traitement des états pathologiques induits par des métalloprotéinases matricielles et l'enzyme TACE, notamment la croissance tumorale, l'arthrose et la perte de cartilage dégénérative.

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