2,(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles

Details 2,(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles 2,(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles

C - Chemistry, Metallurgy

07

D

260/308.5

C07D 277/56 (2006.01)

Patent

CA 1158247

2-(3,4,5-TRIMETHOXYPHENYL)-4,5-DISUBSTITUTED THIAZOLES ABSTRACT OF THE DISCLOSURE 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles, having the general formula (I): Image (I) wherein R1 represents an alkyl group of C1 to C3, and R2 represents a hydrogen atom, an alkyl group of C1 to C3, acetyl group, carbamoyl group, hydrazinocarbonyl group, carboxyl group, esterified carboxyl group by lower alcohol of C1 to C3 or further, acetyl group in which the carbonyl group has been converted to C=NOH group, C=NOCOCH3 group, C=N-WHCONH2 group, C=N-NHCSNH2 group or C=NHC(NH)NH2 group with a proviso that both R1 and R2 are not hydrogen atoms simultaneously, each of which has an anti-peptic ulcer activity, and methods for producing the same are disclosed herein. Such methods include cyclization to a thiazole ring by the condensation of trimethoxybezamide and alpha-halogenoketone, and three other disclosed synthesizations.

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