2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and...

Details 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and... 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and...

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61K 31/439 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2422717

The invention provides 2, 3-, 4- or 5-substituted-N1-(benzensulfonyl)indoles compounds of the general formula (I) in which Ar, R2, R3, R4 and R5 are as defined in the specification. The said compounds have affinity for the 5-HT6 receptor and are useful for the treatment and prophylaxis of disorders relating to the said receptor, such as obesity and CNS disorders.

L'invention concerne des composés N1-(benzensulfonyl)indoles substitués en 3, 4 ou 5 de la formule générale (I) où Ar, R?2¿, R?3¿, R?4¿ et R?5¿ ont la définition donnée dans la description. Ces composés ont une affinité pour le récepteur 5-HT¿6? et sont utiles pour traiter et prévenir les troubles liés à ce récepteur, tels que l'obésité et les troubles du système nerveux central.

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