2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives

Details 2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives 2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives

C - Chemistry, Metallurgy

07

D

167/240, 260/319

C07D 209/10 (2006.01) A61K 31/40 (2006.01) C07D 209/12 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1247626

Abstract of the Disclosure: A compound represented by the formula Image (I) wherein R1 represents a lower alkyl group; each of R2 and R3 represents an alkyl group having 1 to 3 carbon atoms; and each of R4, R5 and R6 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, an aralkyloxy group, a lower alkylthio group, a lower haloalkyl group, a hydroxyl group, a cyano group, a nitro group, an amino group, a mono- or di-(lower alkyl or aralkyl)amino group or a group of the formula Image or Image in which R7 represents a lower alkylene group having at least 2 carbon atoms, one of R8 and R9 represents a hydrogen atom or a lower alkyl group and the other represents a lower alkyl group, and R10 represents a hydrogen atom or a lower alkyl group; or any two of R4, R5 and R6 which are adjacent to each other, together, represent a lower alkylenedioxy group, and a salt thereof; and a process for production thereof. This compound has 5-lipoxygenase inhibiting activity and is useful as a medicament.

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