2,3-alkylene bis(oxy)benzoic acids

Details 2,3-alkylene bis(oxy)benzoic acids 2,3-alkylene bis(oxy)benzoic acids

C - Chemistry, Metallurgy

07

D

260/354.1, 260/2

C07D 319/18 (2006.01) C07D 321/10 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1137472

ABSTRACT OF THE DISCLOSURE The invention relates to novel 2,3-alkylene bis(oxy)- benzoic acids of the formula: Image I wherein A represents a C1-3 alkylene chain, which may or may not be substituted by a C1-4 alkyl, a C2-4 alkenyl or a C1-4 hydroxyalkyl group; X represents hydrogen, a halogen atom, hydroxy, amino, a substituted amino, a C1-4 alkoxy or a C1-4 alkyl group; Y represents hydrogen, a halogen atom, hydroxy, amino, a substituted amino, nitro, a C1-4 alkoxy, C1-4 alkyl- sulfonyl, adamantylsulfonyl, a cycloalkylsulfonyl, a sulfonyl group substituted by an amino, mono- or disubstituted NR3R4 amino group, in which R3 and R4 which can be the same or different are: hydrogen atoms, or groups C1-4 alkyl, C2-4 alkenyl, C2-4 alkinyl, phenyl, benzyl, cycloalkyl, cycloalkane- alkyl, cycloalkenealkyl, bicycloalkyl, adamantyl, pyrimidinyl, pyrazinyl or alkyl substituted by a hydroxy, mercapto, acyl, thioacyl, alkoxy or alkylthio group, or form together, with the nitrogen atom to which they are attached, a heterocycle which may possibly contain another heteroatom; Z represents a hydro- gen or halogen atom, a hydroxy or amino or aminosubstituted group, or nitro, a C1-4 alkoxy; X and Y or Y and Z can be con- nected together through a substituted or unsubstituted carbon chain, or through other heteroatoms to form a cycle such as substituted or unsubstituted triazole, imidazole, oxazole, thiadiazole, pyrazine, piperazine, diazepine and their oxides. The intermediates are useful in the preparation of novel 2,3-alkylene bis(oxy)benzamides which are useful thera- peutic agents.

293596

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