2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/04 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 277/42 (2006.01) C07D 277/56 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2494695

The present invention relates to novel compounds selected from 2-(3-aminoaryl) amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors of the following formula: (see above formula)

La présente invention concerne des composés pris dans des 2-(3-aminoaryl)amino-4-aryl-thiazoles représentés par la formule (I) qui modulent, régulent, et/ou inhibent sélectivement la transduction de signaux induits par certaines tyrosines kinases natives et/ou mutantes impliquées dans diverses pathologies de l'homme ou de l'animal telles que troubles de la prolifération cellulaire, du métabolisme, manifestations allergiques et maladies dégénératives. Plus particulièrement, ces composés sont des inhibiteurs puissants et sélectifs de c-kit.

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