2,3-benzodiazepine derivatives and their use as...

Details 2,3-benzodiazepine derivatives and their use as... 2,3-benzodiazepine derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 243/02 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2244777

The invention concerns compounds of formula (I), in which: X designates hydrogen or halogen; Y designates -NR3- or -N=; R1, R2 and R3 designate hydrogen or different substituents; R4 designates optionally substituted C1-C6 alkyl; R5 designates hydrogen; or R4 and R5 together designate oxygen; R6 designates C1-C4 alkyl; and (a) designates a double bond or single bonds. Owing to their non-competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.

L'invention concerne des composés de la formule (I), dans laquelle X désigne hydrogène ou halogène, Y désigne -NR<3>- ou -N=, R<1>, R<2> et R<3> désignent hydrogène ou différents substituants, R<4> désigne alkyle C1-C6 éventuellement substitué, R<5> désigne hydrogène, ou R<4> et R<5> désignent conjointement oxygène, R<6> désigne alkyle C1-C4 et (a) désigne une liaison double ou des liaisons simples. L'action inhibitrice non compétitive que ces dérivés exercent sur les récepteurs d'AMPA leur permet d'être utilisés comme médicaments pour traiter des affections du système nerveux central.

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