2',3'-dideoxy-4'-thioribonucleosides as antiviral agents

Details 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07D 409/04 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2080916

2080916 9116333 PCTABS00007 2',3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of formula (I), where X = H, N3 or F, and B is a member selected from the group consisting of pyrimidine, 5-azapyrimidine, 6-azapyrimidine, 3-deazapyrimidine, purine, 3-deazapurine, 7-deazapurine, 8-azapurine, and 2-azapurine bases. The intermediate 1-0-acetyl-5-0-t-butyldiphenylsilyl-4-thio-2,3-dideoxyribofuranose useful in the production of certain of the 2',3'-dideoxy-4'-thioribonucleosides is also disclosed.

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