2,3-dihalo-2,3-(disubstituted)propanoate antimicrobial...

C - Chemistry – Metallurgy – 07 – C

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260/387.1, 260/4

C07C 69/62 (2006.01)

Patent

CA 1191148

ABSTRACT OF THE DISCLOSURE Antimicrobial compounds of the formula: Image (I.) wherein Hal is bromine or chlorine; R is C1-4 alkyl, straight or branched chain; and one of R1 and R2 is hydrogen and the other is selected from the group consisting of -(CH2)nCOOR, where R has the same meaning as above and n is 0 to 6; C1-12 alkyl, straight or branched chain; C3-8 cycloalkyl; C3-8 cycloalkyl C1-3 alkyl: phenyl; phenyl C1-3 alkyl; mono- or disubstituted phenyl or phenyl C1-3 alkyl. wherein the substituents are halo, C1-4 alkyl, C1-4 alkoxy, hydroxy, nitro, cyano, or trifluoromethyl; a heterocyclic radical selected from the group consisting of thienyl, furanyl, pyrrolyl, isoxazolyl, oxazolyl, isothiazolyl, thiazolyl, pyrazolyl, imidazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, and pyridinyl, and N-oxides thereof; and a saturated heterocyclic radical selected from the group consisting of pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, isoxazolidinyl, oxazolidinyl, isothiazolidinyl, thiazolidinyl, pyrazolidinyl, imidazolidinyl, piperazinyl, and piperidinyl.

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