2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives...

Details 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives... 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/495 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2127084

The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 Image wherein - R1 is halogen, lower alkyl or alkoxy, hydroxy, trifluoromethyl or cyano, - m has the value 1 or 2 and n has the value 0 or 1, - A represents an alkylene chain containing 2-6 C-atoms which may be substituted with one or more lower alkyl groups or a monocyclic (hetero)aryl group, and - B is methylene, ethylene, carbonyl, sulfinyl, sulfonyl or sulfur, and salts thereof.

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