2,3-dihydro-4(1h)-quinazolinones active in gastro-intestinal...

Details 2,3-dihydro-4(1h)-quinazolinones active in gastro-intestinal... 2,3-dihydro-4(1h)-quinazolinones active in gastro-intestinal...

C - Chemistry, Metallurgy

07

D

C07D 239/88 (2006.01) C07D 239/90 (2006.01) C07D 265/22 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2120215

This invention refers to heterocyclic compounds of general formula Image wherein: m is a whole number between 2 and 3; R1 and R2, independently, are an atom of hydrogen or a (C1-C3)-alkyl radical or R1 and R2 taken together with the atom of nitrogen form a heterocyclic ring; R3 is an atom of hydrogen or a (C1-C10)-alkyl radical with linear, branched or cyclic chain, or a benzyl radical; R6 is chlorine; R4, R5 and R7 are independently an atom of H or a C1-C6 alkyl radical with linear or branched chain, and their pharmacologically-acceptable salts. The derivatives described in this invention are active in the gastro-intestinal organs; in particular, they have prokinetic effects, in other words they create specific stimulation on gastro-intestinal motility, facilitating the passage of the contents of the alimentary tract, and possess anti-emetic qualities, without side effects involving the central nervous system.

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