C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/41 (2006.01) A61P 31/00 (2006.01) C07D 235/00 (2006.01) C07D 263/00 (2006.01)
Patent
CA 2539335
The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
Composé 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole de formule générale (1) dans laquelle R?1¿ représente un atome d'hydrogène ou un groupe alkyle C1-C6, n représente un nombre entier de 0 à 6, R?1¿ et -(CH¿2?)¿n?R?2¿ peuvent former un cycle spiro de formule (30), avec l'atome de carbone adjacent (dans la formule (30), RRR représente un groupe pipéridyle qui peut posséder des substituants sur le cycle pipéridine), et R?2¿ représente un groupe benzothiazolyloxy, un groupe quinolyloxy, un groupe pyridyloxy ou analogue. Le composé selon la présente invention possède une excellente action bactéricide contre Mycobacterium tuberculosis, Mycobacterium tuberculosis multirésistant et les bactéries acido-alcoolo-résistantes atypiques.
Haraguchi Yoshikazu
Hasegawa Takeshi
Hashizume Hiroyuki
Itotani Motohiro
Kawasaki Masanori
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Co. Ltd.
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