2,3-dihydro-imidazo [1,2-b] pyridazine derivatives, their...

Details 2,3-dihydro-imidazo [1,2-b] pyridazine derivatives, their... 2,3-dihydro-imidazo [1,2-b] pyridazine derivatives, their...

C - Chemistry, Metallurgy

07

D

260/264.3

C07D 487/04 (2006.01)

Patent

CA 1155118

- 16 - ABSTRACT "2,3-DIHYDRO-IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE" 2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives of the formula: Image in which R1 represents a phenyl, halogenophenyl, trifluoromethylphenyl, C(1-4)-alkylphenyl, (C1-4)- alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C1-4)-alkylaminophenyl, di-(C1-4)-alkylaminophenyl, acetamidophenyl, thienyl, pyridyl, furyl or nitrofuryl radical, R2 represents a hydrogen atom or a (C1-4)- alkyl radical, and R3 represents a hydrogen atom or a (C1-4)-alkyl, phenyl, halogenophenyl, trifluoromethyl- phenyl, (C1-4)-alkylphenyl, (C1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C1-4)- alkylaminophenyl, di-(C1-4)-alkylaminophenyl or acetamidophenyl radical, and its addition salts with pharmaceutically acceptable acids are useful in therapy - 17 - as antidepressants. They may be made by cyclization of compounds of the formula: Image

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