2,3-dihydrobenzofuran derivatives

Details 2,3-dihydrobenzofuran derivatives 2,3-dihydrobenzofuran derivatives

C - Chemistry, Metallurgy

07

D

C07D 307/81 (2006.01) A61K 31/34 (2006.01)

Patent

CA 2151503

Disclosed are a 2,3-dihydrobenzofuran derivative represented by formula (1) or a salt thereof, a method for producing the same, and use thereof: (see fig. I) wherein R1 represents a hydrogen atom or a lower alkyl group; n is an integer of from 2 to 6; A represents a carbonyl group or a sulfonyl group; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group (which is unsubstituted or substituted with at least one halogen atom), a lower alkoxy group, a hydroxyl group, a nitro group or a cyano group; and * represents an asymmetric carbon atom. A 2,3-dihydrobenzofuran derivative of the present invention or a salt thereof has a strong affinity for a serotonin 1A receptor, and, therefore, is useful for prevention and treatment of serotonergic neuron-related diseases, such as anxiety, depression, high blood pressure, emeses (including emeses induced by motion sickness, space sickness and dizziness, etc.) and the like.

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