C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/59 (2006.01) A61K 31/12 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/40 (2006.01) A61K 31/455 (2006.01) A61K 31/505 (2006.01) C07C 49/517 (2006.01) C07C 62/26 (2006.01) C07C 62/38 (2006.01) C07C 69/12 (2006.01) C07C 69/757 (2006.01) C07C 69/96 (2006.01) C07C 233/47 (2006.01) C07C 317/50 (2006.01) C07C 323/22 (2006.01) C07C 323/41 (2006.01) C07D 213/80 (2006.01) C07D 239/38 (2006.01) C07D 317/22 (2006.01) C07D 317/72 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2246054
Compounds represented by general formula (I) and pharmacologically acceptable salts thereof {excluding (1R,2S)-2-[(2R)-(2-acetylamino-2- carboxyethyl)thiomethyl]-3-oxo-1-cyclopentanecarboxylic acid (cystacycline)}, wherein X represents O, S, SO, SO2, or NH; Y represents a C1-6 (un)substituted hydrocarbon residue having a molecular weight of 15 to 400, provided that when it is cyclic, it may contain one or two heteroatoms; and Z represents carboxy, a group derived therefrom, or a C1-4 (un)substituted aliphatic hydrocarbon residue. The compounds are useful as a neuron differentiation accelerator.
L'invention porte sur des composés de formule générale (I) et leurs sels pharmacocompatibles [à l'exception de l'acide (1R,2S)-2-[(2R)-(2-acétylamino-2-carboxyéthyl)thiométhyl]-3-oxo-1-cyclopentanecarboxylique (cystacycline)]. Dans ladite formule, X représente O, S, SO, ou NH; Y représente un résidu hydrocarboné C¿1-6? substitué ou non, d'un poids moléculaire compris entre 15 et 400, qui, sous réserve d'être cyclique, peut contenir un ou deux hétéroatomes; et Z représente carboxy, un groupe en dérivant, ou un résidu aliphatique hydrocarboné C¿1-4? substitué ou non. Lesdits composés servent d'accélérateurs de la différenciation des neurones.
Masuda Kuniko
Morino Tomio
Saito Seiichi
Nippon Kayaku Kabushiki Kaisha
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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