2,3-disubstituted isoxazolidines, a process for their...

Details 2,3-disubstituted isoxazolidines, a process for their... 2,3-disubstituted isoxazolidines, a process for their...

C - Chemistry, Metallurgy

07

K

167/235, 260/304

C07K 5/04 (2006.01) A61K 31/535 (2006.01) A61K 38/04 (2006.01) C07D 261/02 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 5/093 (2006.01) C07K 5/097 (2006.01)

Patent

CA 1338484

The invention relates to compounds of the formula Image (I) in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; B represents CO, CS, C=NH, CN-alkyl, CN-O- alkyl, SO, optionally substituted CH2 or a bond; D rep- resents NH, NCH3, O, CH2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C=NH; F represents O, NH, NCH3 or a bond; R4 denotes an optionally substitu- ted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.

554535

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