2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazoline-4-yl)...

Details 2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazoline-4-yl)... 2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazoline-4-yl)...

C - Chemistry, Metallurgy

07

D

C07D 239/84 (2006.01) A61K 31/517 (2006.01) A61P 31/22 (2006.01)

Patent

CA 2515545

The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses. In a specific embodiment, the invention relates to compound of the formula (see formula I) in which Ar represents aryl which may be substituted by 1 to 3 substituents, etc., R1 represents hydrogen, alkyl, alkoxy, etc., R2 represents hydrogen, alkyl, alkoxy, etc., R3 represents alkyl, alkoxy, cyano, etc., or one of the radicals R1, R2 and R3 represents hydrogen, alkyl, alkoxy, etc., R4 represents hydrogen or alkyl, R5 represents hydrogen or alkyl, or the radicals R4 and R5 are attached to carbon atoms directly opposing each other in the piperazine ring and form a methylene bridge which is optionally substituted by 1 or 2 methyl groups, or a salt, a solvate or a solvate of a salt thereof.

L'invention concerne des dihydrochinazolines, des procédés de fabrication de celles-ci, leur utilisation dans le traitement et/ou la prophylaxie de maladies, et leur utilisation dans la fabrication d'agents pharmaceutiques servant au traitement et/ou à la prophylaxie de maladies, notamment leur utilisation en tant qu'agents antiviraux, en particulier contre des cytomégalovirus.

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