2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine...

Details 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine... 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/4439 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2554925

The present invention relates to novel compounds selected from 2- (3~substitutedaryl)amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors.

L'invention concerne de nouveaux composés sélectionnés parmi des 2-(3-substitués aryle)amino-4-aryle-thiazoles qui modulent, régulent et/ou inhibent sélectivement la transduction de signaux induite par certaines tyrosine kinases natives et/ou mutantes impliquées dans plusieurs maladies humaines et animales telles que la prolifération cellulaire, les troubles du métabolisme, les allergies et les maladies dégénératives. Ces composés sont en particulier des inhibiteurs potentiels et sélectifs de c-kit.

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