2,3-substituted pryidl compounds useful for treating pain

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/495 (2006.01) A61P 1/04 (2006.01) A61P 13/02 (2006.01) C07D 213/00 (2006.01) C07D 241/00 (2006.01)

Patent

CA 2534088

Compounds of formulae (I) and (II) where X is S or O and Ar2, R1, R2, R3, R8, n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a "3-substituted Pyridyl Compound"), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.

La présente invention concerne des composés représentés par les formules (I) et< >(II) dans lesquelles X représente S ou O et Ar2, R1, R2, R3, R8, n, m et t, ou un sel pharmaceutiquement acceptable de ces derniers (un 'composé pyridyle à substitution 3), des compositions comprenant une quantité efficace d'un composé pyridyle à substitution 3 et des méthodes de traitement ou de prévention de la douleur, de l'incontinence urinaire, des ulcères, de la maladie intestinale inflammatoire, du syndrome du côlon irritable, d'un trouble d'accoutumance, de la maladie de Parkinson, du parkinsonisme, de l'anxiété, de l'épilepsie, de l'accident vasculaire cérébral, de la crise épileptique, d'un état pruritique, de la psychose, d'un trouble cognitif, d'une déficience de la mémoire, d'une limitation des fonctions cérébrales, de la chorée de Huntington, de la sclérose latérale amyotrophique, de la démence, de la rétinopathie, d'un spasme musculaire, d'une migraine, des vomissements, de la dyskinésie ou de la dépression chez un animal, ces méthodes de traitement ou de prévention consistant à administrer à un animal nécessitant un tel traitement, une quantité efficace d'un composé pyridyle à substitution 3. Formules (I) et (II)

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