2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors

Details 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 263/38 (2006.01) A61K 31/42 (2006.01)

Patent

CA 2249420

A 2-(3H)-oxazolone compound of formula (I) wherein R1 is an alkyl or -NR4R5 group, wherein R4 and R5 each independently is hydrogen or an alkyl or benzyl group; R2 is a naphthyl, tetrahydronaphthyl, unsubstituted phenyl or phenyl group, substituted by from 1 to 3 halogen atoms or alkyl, hydroxy, alkoxy or trifluoromethyl groups; and R3 is hydrogen or an alkyl group.

L'invention concerne un composé de 2-(3H)-oxazolone présentant la formule (I) où R?1¿ est un groupe alkyle ou -NR?4¿R?5¿, dans lequel R?4¿ et R?5¿ sont chacun, indépendamment, de l'hydrogène ou un groupe alkyle ou benzyle; R?2¿ est un groupe naphtyle, tétrahydronaphtyle, phényle non substitué ou un groupe phényle, substitué par 1 à 3 atomes d'halogène ou de l'alkyle, de l'hydroxy, de l'alkoxy ou des groupes trifluorométhyle et R?3¿ est de l'hydrogène ou un groupe alkyle.

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