2,4,5-trimethyl-thieno (3,2-f) morphan, and intermediates

C - Chemistry – Metallurgy – 07 – D

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260/279.4, 260/2

C07D 409/06 (2006.01) C07D 213/50 (2006.01) C07D 213/84 (2006.01) C07D 333/22 (2006.01)

Patent

CA 1068279

ABSTRACT OF THE DISCLOSURE 2,4,5-Trimethyl-theino[3,2-f]morphan, a comound having analegisic activity, is prepared from 3,4-dimethylpyridine-N-oxide via series of intermediates: 2-cyano-4,5-dimethlpyridine, 2-thienyl-(4,5-dimethyl-2- pyridyl)-ketoned, 2-(2-thienyl)-4,5-dimethylpyridine and 2-(2-thienyl)-1,4,5- trimethyl-1,2,3,6-tetrahydropyridine which are novel compounds and mostly also show analgesic activity.

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