C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/273
C07D 471/18 (2006.01) C07D 471/08 (2006.01) C07D 471/10 (2006.01)
Patent
CA 1259998
ABSTRACT OF THE DISCLOSURE A compound corresponding to the formula: (Vb) Image wherein R1 and R2 independently from each other denote hydrogen, a substituent which contains up to 12 carbon atoms and which is selected from the group consisting of alkyl, alkenyl, and alkinyl, or a cycloalkyl group containing 3 to 6 carbon atoms which is attached to the nitrogen atom directly or by an alkylene group containing 1 to 3 carbon atoms, and R3 and R4 each denotes an alkyl group containing 1 to 7 carbon atoms, or both together form an alkylene chain represented by the formula -(CH2)n- wherein n is an integer ranging between 3 and 6, with the proviso that when R1 and R2 each are hydro- gen, R3 and R4 do not denote methyl and do not together form a tetramethylene or pentamethylene group and when one of R1 and R2 is hydrogen and the other is methyl or ethyl, only one of R3 and R4 may be methyl and R3 and R4 may not together form a tetramethylene or a penta- methylene group, or if none of R1 and R2 is hydrogen the substituents R1, R2, R3 and R4 together contain at least 5 carbon atoms. The preparation of this compound is also disclosed. This compound is useful for the preparation of 3,7-diaza bicyclo-(3,3,1)-nonane compounds which exert a favorable reaction between anti-arythmic activity, or the prolongation of the cardiac refractory period and negative inotropic side effects.
579322
Buschmann Gerd
Hachmeister Bernd
Kehrbach Wolfgang
Kuhl Ulrich
Schoen Uwe
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Solvay Pharmaceuticals Gmbh
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