2,4,6-triamino-1,3,5-triazine derivative

Details 2,4,6-triamino-1,3,5-triazine derivative 2,4,6-triamino-1,3,5-triazine derivative

C - Chemistry, Metallurgy

07

D

C07D 251/70 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61P 25/28 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2475432

This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6--triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.

L'invention concerne un médicament contre la démence contenant un inhibiteur de canal potassique BEC1 en tant que principe actif. Il est démontré qu'un inhibiteur de canal potassique BEC1 possède un effet d'amélioration de l'incapacité d'apprentissage et qu'il est utile en tant que préventif ou remède dans les maladies dans lesquelles le canal potassique BEC1 semble participer, de préférence la démence. Plus spécifiquement, il est confirmé qu'un inhibiteur de canal potassique BEC1 montre un effet d'amélioration de l'incapacité d'apprentissage dans un test in vivo. Il est aussi démontré qu'un composé possédant une structure de 2,4,6-triamino-1,3,5-triazine possède un effet d'inhibition du canal potassique BEC1.

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